Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4+ T Cell Immunity

Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4+ T Cell Immunity

Bacillus anthracis produces a binary toxin composed of protective antigen (PA) and one of two subunits, lethal factor (LF) or edema factor (EF). Most studies have concentrated on induction of toxin-specific antibodies as the correlate of protective immunity, in contrast to which understanding of ce...

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Bibliographic Details
Main Authors: Ascough, Stephanie, Ingram, Rebecca J., Chu, Karen K., Reynolds, Catherine J., Musson, Julie A., Doganay, Mehmet, Metan, Gökhan, Ozkul, Yusuf, Baillie, Les, Sriskandan, Shiranee, Moore, Stephen J., Gallagher, Theresa B., Dyson, Hugh, Williamson, E. Diane, Robinson, John H., Maillere, Bernard, Boyton, Rosemary J., Altmann, Daniel M.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006929/

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