Paradoxic effects of metformin on endothelial cells and angiogenesis

Paradoxic effects of metformin on endothelial cells and angiogenesis

We have investigated the effect of metformin on the mechanisms of angiogenesis. We show that metformin, particularly in the context of obesity, inhibits angiogenesis in vivo yet shows a contradictory effect on angiogenesis-related genes and proteins that involve AMPK.

Bibliographic Details
Main Authors: Dallaglio, Katiuscia, Bruno, Antonino, Cantelmo, Anna R., Esposito, Alessia I., Ruggiero, Luca, Orecchioni, Stefania, Calleri, Angelica, Bertolini, Francesco, Pfeffer, Ulrich, Noonan, Douglas M., Albini, Adriana
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004203/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004203/

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