Identification of Chromosome Sequence Motifs That Mediate Meiotic Pairing and Synapsis in C. elegans

C. elegans chromosomes contain specialized regions called pairing centers (PCs) that mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, -2, -3, and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence el...

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Bibliographic Details
Main Authors: Phillips, Carolyn M., Meng, Xiangdong, Zhang, Lei, Chretien, Jacqueline H., Urnov, Fyodor D., Dernburg, Abby F.
Format: Online
Language:English
Published: 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001799/