Removal of immunoglobulin-like domains from titin’s spring segment alters titin splicing in mouse skeletal muscle and causes myopathy

Changes in titin splicing resulting in decreased size and increased stiffness lead to pathological changes in skeletal muscle.

Bibliographic Details
Main Authors: Buck, Danielle, Smith, John E., Chung, Charles S., Ono, Yasuko, Sorimachi, Hiroyuki, Labeit, Siegfried, Granzier, Henk L.
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001778/