Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed-Pharmacogenomics

Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed-Pharmacogenomics

Though aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples enabling detailed mapping of pathways involved in drug response. We defined the metabolic s...

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Bibliographic Details
Main Authors: Yerges-Armstrong, Laura M., Ellero-Simatos, Sandrine, Georgiades, Anastasia, Zhu, Hongjie, Lewis, Joshua, Horenstein, Richard B., Beitelshees, Amber L., Dane, Adrie, Reijmers, Theo, Hankemeier, Thomas, Fiehn, Oliver, Shuldiner, Alan R., Kaddurah-Daouk, Rima
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001726/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001726/

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