Combined staurosporine and retinoic acid induces differentiation in retinoic acid resistant acute promyelocytic leukemia cell lines

Combined staurosporine and retinoic acid induces differentiation in retinoic acid resistant acute promyelocytic leukemia cell lines

All-trans retinoic acid (ATRA) resistance has been a critical problem in acute promyelocytic leukemia (APL) relapsed patients. In ATRA resistant APL cell lines NB4-R1 and NB4-R2, the combination of staurosporine and ATRA synergized to trigger differentiation accompanied by significantly enhanced pro...

Full description

Bibliographic Details
Main Authors:	Ge, Dong-zheng, Sheng, Yan, Cai, Xun
Format:	Online
Language:	English
Published:	Nature Publishing Group 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001092/

Similar Items

Retinoic Acid and Arsenic for Treating Acute Promyelocytic Leukemia
by: Zhou, Guang-Biao, et al.
Published: (2005)

All-trans-retinoic acid–induced pseudotumor cerebri in acute promyelocytic leukemia
by: Anoop, T. M., et al.
Published: (2014)

Significance of ETV6 rearrangement in acute promyelocytic leukemia with t(15;17)/promyelocytic leukemia/retinoic acid receptor alpha
by: GAO, NA, et al.
Published: (2016)

Granulocyte colony-stimulating factor potentiates all-trans retinoic acid-induced granulocytic differentiation in acute promyelocytic leukemia cell line HT93A
by: Uchino, Yoshihito, et al.
Published: (2015)

SCROTAL ULCERATION FOLLOWING ALL-TRANS RETINOIC ACID THERAPY FOR ACUTE PROMYELOCYTIC LEUKEMIA
by: Tazi, Illias, et al.
Published: (2011)

Acute Promyelocytic Leukemia: an Experience on 95 Greek Patients Treated in the All-Trans-Retinoic Acid Era
by: Pagoni, Maria, et al.
Published: (2011)

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
Published: (1990)

Retinoic Acid and Arsenic Synergize to Eradicate Leukemic Cells in a Mouse Model of Acute Promyelocytic Leukemia
by: Lallemand-Breitenbach, Valérie, et al.
Published: (1999)

Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)☆
by: Ryan W. Holloway, et al.
Published: (2018-09-01)

Sweet’s syndrome during the treatment of acute promyelocytic leukemia with all-trans retinoic acid
by: Park, Chi Jun, et al.
Published: (2001)

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
by: Wei, Shuo, et al.
Published: (2015)

A Complicated Case of Acute Promyelocytic Leukemia in the Second Trimester of Pregnancy Successfully Treated with All-trans-Retinoic Acid
by: Agarwal, Kanika, et al.
Published: (2015)

Bcl-2 Cooperates with Promyelocytic Leukemia Retinoic Acid Receptor α Chimeric Protein (Pmlrarα) to Block Neutrophil Differentiation and Initiate Acute Leukemia
by: Kogan, Scott C., et al.
Published: (2001)

Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis
by: Manikam, Shiamala Devi, et al.
Published: (2009)

Reversible Symptomatic Myocarditis Induced by All-Trans Retinoic Acid Administration during Induction Treatment of Acute Promyelocytic Leukemia: Rare Cardiac Manifestation as a Retinoic Acid Syndrome
by: Choi, Seonghoon, et al.
Published: (2011)

All-Trans Retinoic Acid plus Arsenic Trioxide versus All-Trans Retinoic Acid plus Chemotherapy for Newly Diagnosed Acute Promyelocytic Leukemia: A Meta-Analysis
by: Ma, Yafang, et al.
Published: (2016)

Budgetary Impact of Treating Acute Promyelocytic Leukemia Patients with First-Line Arsenic Trioxide and Retinoic Acid from an Italian Payer Perspective
by: Kruse, Morgan, et al.
Published: (2015)

Treatment outcome of all-trans retinoic acid/anthracycline combination chemotherapy and the prognostic impact of FLT3/ITD mutation in acute promyelocytic leukemia patients
by: Hong, Seung-Dok, et al.
Published: (2011)

Treatment outcomes in relapsed acute promyelocytic leukemia patients initially treated with all-trans retinoic acid and arsenic compound-based combined therapies
by: LU, JIN, et al.
Published: (2014)

Role of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial
by: Li Zhang, et al.
Published: (2018-04-01)

Detection of Promyelocytic Leukemia/Retinoic Acid Receptor α (PML/RARα) Fusion Gene with Functionalized Graphene Oxide
by: Li, Ran, et al.
Published: (2013)

Retinoic acid and cancer treatment
by: Chen, Mei-Chih, et al.
Published: (2014)

The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
by: Fredly, Hanne, et al.
Published: (2013)

Retinoic acid signaling in axonal regeneration
by: Puttagunta, Radhika, et al.
Published: (2012)

Retinoic acid signaling and the evolution of chordates
by: Marlétaz, Ferdinand, et al.
Published: (2006)

Oral tolerance: is it all retinoic acid?
by: von Boehmer, Harald
Published: (2007)

Retinoic acid on stage in antitumor immunity
by: Guo, Yanxia, et al.
Published: (2013)

Retinoic acid signaling and the evolution of chordates
Published: (2006-04-01)

All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia: A Case Report and Literature Review
by: Holmes, Dylan, et al.
Published: (2012)

Pseudotumour cerebri in acute promyelocytic leukemia on treatment with all-trans-retinoic acid (ATRA) - an experience from a tertiary care centre
by: Farah Nadhirah
Published: (2015)

Arsenic trioxide and all-trans retinoic acid (ATRA) treatment for acute promyelocytic leukemia in all risk groups: study protocol for a randomized controlled trial
by: Xinxin Zhang, et al.
Published: (2018-09-01)

Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide
by: Shen, Yang, et al.
Published: (2015)

Retinoic acid and glycolic acid combination in the treatment of acne scars
by: Chandrashekar, BS, et al.
Published: (2015)

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
by: Yao, Jing, et al.
Published: (2014)

All-Trans Retinoic Acid in Combination with Primaquine Clears Pneumocystis Infection
by: Lei, Guang-Sheng, et al.
Published: (2013)

Role of synthetic retinoic acid derivatives in Chronic Lymphocytic Leukemia and Multiple Myeloma
by: Saeed, Ayman T, et al.
Published: (2013)

Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line
by: Yoon, Suk-Gu, et al.
Published: (2013)

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
by: Boutzen, Héléna, et al.
Published: (2016)

Disruption of Retinoic Acid Receptor Alpha Reveals the Growth Promoter Face of Retinoic Acid
by: Somenzi, Giulia, et al.
Published: (2007)

EMBO Retinoids 2011: mechanisms, biology and pathology of signaling by retinoic acid and retinoic acid receptors
by: McKenna, Neil J.
Published: (2012)