Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

A common key regulator of oncogenic signaling pathways in multiple tumor types is the unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and potency. Using mechanism-based screening, here we find that all-trans retinoic acid (ATRA)--a therapy for acute promyelocy...

Full description

Bibliographic Details
Main Authors: Wei, Shuo, Kozono, Shingo, Kats, Lev, Nechama, Morris, Li, Wenzong, Guarnerio, Jlenia, Luo, Manli, You, Mi-Hyeon, Yao, Yandan, Kondo, Asami, Hu, Hai, Bozkurt, Gunes, Moerke, Nathan J., Cao, Shugeng, Reschke, Markus, Chen, Chun-Hau, Rego, Eduardo M., LoCoco, Francesco, Cantley, Lewis, Lee, Tae Ho, Wu, Hao, Zhang, Yan, Pandolfi, Pier Paolo, Zhou, Xiao Zhen, Lu, Kun Ping
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425616/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425616/

Similar Items