Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse
•24S-Hydroxycholesterol is almost absent from brain of the Cyp46a1−/− mouse.•It is not quantitatively replaced by another oxysterol.•Minor amounts of 22R-, 24R-, 25- and (25R),26-hydroxycholesterols are present.•Cholesterol biosynthesis is reduced in brain of the Cyp46a1−/− mouse.•24S,25-Epoxycholes...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Academic Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000437/ |