Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates

Tumor spheroids are increasingly recognized as an important in vitro model for the behavior of tumor cells in three dimensions. More physiologically relevant than conventional adherent-sheet cultures, they more accurately recapitulate the complexity and interactions present in real tumors. In order...

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Main Authors:	Razian, Golsa, Yu, Yang, Ungrin, Mark
Format:	Online
Language:	English
Published:	MyJove Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991351/

id	pubmed-3991351
recordtype	oai_dc
spelling	pubmed-39913512014-04-22 Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates Razian, Golsa Yu, Yang Ungrin, Mark Bioengineering Tumor spheroids are increasingly recognized as an important in vitro model for the behavior of tumor cells in three dimensions. More physiologically relevant than conventional adherent-sheet cultures, they more accurately recapitulate the complexity and interactions present in real tumors. In order to harness this model to better assess tumor biology, or the efficacy of novel therapeutic agents, it is necessary to be able to generate spheroids reproducibly, in a controlled manner and in significant numbers. MyJove Corporation 2013-11-18 /pmc/articles/PMC3991351/ /pubmed/24300192 http://dx.doi.org/10.3791/50665 Text en Copyright © 2013, Journal of Visualized Experiments http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visithttp://creativecommons.org/licenses/by-nc-nd/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Razian, Golsa Yu, Yang Ungrin, Mark
spellingShingle	Razian, Golsa Yu, Yang Ungrin, Mark Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
author_facet	Razian, Golsa Yu, Yang Ungrin, Mark
author_sort	Razian, Golsa
title	Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
title_short	Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
title_full	Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
title_fullStr	Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
title_full_unstemmed	Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
title_sort	production of large numbers of size-controlled tumor spheroids using microwell plates
description	Tumor spheroids are increasingly recognized as an important in vitro model for the behavior of tumor cells in three dimensions. More physiologically relevant than conventional adherent-sheet cultures, they more accurately recapitulate the complexity and interactions present in real tumors. In order to harness this model to better assess tumor biology, or the efficacy of novel therapeutic agents, it is necessary to be able to generate spheroids reproducibly, in a controlled manner and in significant numbers.
publisher	MyJove Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991351/
_version_	1612079705516670976

Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates

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