The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PKCS Deficiency

The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PKCS Deficiency

Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80−/− mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pkcs−/− mice. However, these observations are based on independent...

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Bibliographic Details
Main Authors: Reiling, Erwin, Dollé, Martijn E. T., Youssef, Sameh A., Lee, Moonsook, Nagarajah, Bhawani, Roodbergen, Marianne, de With, Piet, de Bruin, Alain, Hoeijmakers, Jan H., Vijg, Jan, van Steeg, Harry, Hasty, Paul
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989187/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989187/

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