MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters

Mixed-lineage leukemia (MLL) maintains the expression of cellular memory genes during development, while leukemic MLL fusion proteins aberrantly maintain expression of hematopoietic stem cell program genes such as HOXA9 to cause leukemia. However, the molecular mechanism of gene activation is unclea...

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Bibliographic Details
Main Authors: Okuda, Hiroshi, Kawaguchi, Marie, Kanai, Akinori, Matsui, Hirotaka, Kawamura, Takeshi, Inaba, Toshiya, Kitabayashi, Issay, Yokoyama, Akihiko
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985622/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985622/

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