MLL Becomes Functional through Intra-Molecular Interaction Not by Proteolytic Processing

MLL Becomes Functional through Intra-Molecular Interaction Not by Proteolytic Processing

The mixed lineage leukemia (MLL) protein is an epigenetic transcriptional regulator that controls proliferative expansion of immature hematopoietic progenitors, whose aberrant activation triggers leukemogenesis. A mature MLL protein is produced by formation of an intra-molecular complex and proteoly...

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Bibliographic Details
Main Authors: Yokoyama, Akihiko, Ficara, Francesca, Murphy, Mark J., Meisel, Christian, Hatanaka, Chikako, Kitabayashi, Issay, Cleary, Michael L.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769346/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769346/

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