Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics

Aim. Identification of women with moderate alcohol abuse during pregnancy is difficult. We correlated self-reported alcohol consumption during pregnancy and patient characteristics with objective alcohol indicators measured in fetal meconium. Methods. A total of 557 women singleton births and avail...

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Main Authors:	Goecke, Tamme W., Burger, Pascal, Fasching, Peter A., Bakdash, Abdulsallam, Engel, Anne, Häberle, Lothar, Voigt, Franziska, Faschingbauer, Florian, Raabe, Eva, Maass, Nicolai, Rothe, Michael, Beckmann, Matthias W., Pragst, Fritz, Kornhuber, Johannes
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985164/

id	pubmed-3985164
recordtype	oai_dc
spelling	pubmed-39851642014-05-05 Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics Goecke, Tamme W. Burger, Pascal Fasching, Peter A. Bakdash, Abdulsallam Engel, Anne Häberle, Lothar Voigt, Franziska Faschingbauer, Florian Raabe, Eva Maass, Nicolai Rothe, Michael Beckmann, Matthias W. Pragst, Fritz Kornhuber, Johannes Research Article Aim. Identification of women with moderate alcohol abuse during pregnancy is difficult. We correlated self-reported alcohol consumption during pregnancy and patient characteristics with objective alcohol indicators measured in fetal meconium. Methods. A total of 557 women singleton births and available psychological tests, obstetric data and meconium samples were included in statistical analysis. Alcohol metabolites (fatty acid ethyl esters (FAEEs) and ethyl glucuronide (EtG)), were determined from meconium and correlated with patient characteristics. Results. We found that 21.2% of the 557 participants admitted low-to-moderate alcohol consumption during pregnancy. Of the parameters analyzed from meconium, only EtG showed an association with alcohol history (P < 0.01). This association was inverse in cases with EtG value above 120 ng/g. These values indicate women with most severe alcohol consumption, who obviously denied having consumed alcohol during pregnancy. No other associations between socioeconomic or psychological characteristics and the drinking status (via meconium alcohol metabolites) could be found. Conclusion. Women who drink higher doses of ethanol during pregnancy, according to metabolite measures in meconium, might be less likely to admit alcohol consumption. No profile of socioeconomic or psychological characteristics of those women positively tested via meconium could be established. Hindawi Publishing Corporation 2014 2014-03-30 /pmc/articles/PMC3985164/ /pubmed/24800249 http://dx.doi.org/10.1155/2014/702848 Text en Copyright © 2014 Tamme W. Goecke et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Goecke, Tamme W. Burger, Pascal Fasching, Peter A. Bakdash, Abdulsallam Engel, Anne Häberle, Lothar Voigt, Franziska Faschingbauer, Florian Raabe, Eva Maass, Nicolai Rothe, Michael Beckmann, Matthias W. Pragst, Fritz Kornhuber, Johannes
spellingShingle	Goecke, Tamme W. Burger, Pascal Fasching, Peter A. Bakdash, Abdulsallam Engel, Anne Häberle, Lothar Voigt, Franziska Faschingbauer, Florian Raabe, Eva Maass, Nicolai Rothe, Michael Beckmann, Matthias W. Pragst, Fritz Kornhuber, Johannes Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics
author_facet	Goecke, Tamme W. Burger, Pascal Fasching, Peter A. Bakdash, Abdulsallam Engel, Anne Häberle, Lothar Voigt, Franziska Faschingbauer, Florian Raabe, Eva Maass, Nicolai Rothe, Michael Beckmann, Matthias W. Pragst, Fritz Kornhuber, Johannes
author_sort	Goecke, Tamme W.
title	Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics
title_short	Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics
title_full	Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics
title_fullStr	Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics
title_full_unstemmed	Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics
title_sort	meconium indicators of maternal alcohol abuse during pregnancy and association with patient characteristics
description	Aim. Identification of women with moderate alcohol abuse during pregnancy is difficult. We correlated self-reported alcohol consumption during pregnancy and patient characteristics with objective alcohol indicators measured in fetal meconium. Methods. A total of 557 women singleton births and available psychological tests, obstetric data and meconium samples were included in statistical analysis. Alcohol metabolites (fatty acid ethyl esters (FAEEs) and ethyl glucuronide (EtG)), were determined from meconium and correlated with patient characteristics. Results. We found that 21.2% of the 557 participants admitted low-to-moderate alcohol consumption during pregnancy. Of the parameters analyzed from meconium, only EtG showed an association with alcohol history (P < 0.01). This association was inverse in cases with EtG value above 120 ng/g. These values indicate women with most severe alcohol consumption, who obviously denied having consumed alcohol during pregnancy. No other associations between socioeconomic or psychological characteristics and the drinking status (via meconium alcohol metabolites) could be found. Conclusion. Women who drink higher doses of ethanol during pregnancy, according to metabolite measures in meconium, might be less likely to admit alcohol consumption. No profile of socioeconomic or psychological characteristics of those women positively tested via meconium could be established.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985164/
_version_	1612077537671774208

Meconium Indicators of Maternal Alcohol Abuse during Pregnancy and Association with Patient Characteristics

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