Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

Recent studies have propagated the model that the mitochondrial unfolded protein response (UPRmt) is causal for lifespan extension from inhibition of the electron transport chain (ETC) in C. elegans. Here we report a genome-wide RNAi screen for negative regulators of the UPRmt. Lifespan analysis of...

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Bibliographic Details
Main Authors: Bennett, Christopher F., Wende, Helen Vander, Simko, Marissa, Klum, Shannon, Barfield, Sarah, Choi, Haeri, Pineda, Victor V., Kaeberlein, Matt
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984390/

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