Inhibition of Smurf2 translation by miR-322/503 modulates TGF-β/Smad2 signaling and intestinal epithelial homeostasis

Inhibition of Smurf2 translation by miR-322/503 modulates TGF-β/Smad2 signaling and intestinal epithelial homeostasis

Smurf2 is an E3 ubiquitin ligase that regulates TGF-β/Smad signaling and is implicated in a wide variety of cellular responses. miR-322 and miR-503 repress Smurf2 translation and thus modulate TGF-β/Smad2 signaling and intestinal epithelial homeostasis.

Bibliographic Details
Main Authors: Cao, Shan, Xiao, Lan, Rao, Jaladanki N., Zou, Tongtong, Liu, Lan, Zhang, Dee, Turner, Douglas J., Gorospe, Myriam, Wang, Jian-Ying
Format: Online
Language:English
Published: The American Society for Cell Biology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982989/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982989/

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