A Central Role for GRB10 in Regulation of Islet Function in Man

A Central Role for GRB10 in Regulation of Islet Function in Man

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mo...

Full description

Bibliographic Details
Main Authors: Prokopenko, Inga, Poon, Wenny, Mägi, Reedik, Prasad B, Rashmi, Salehi, S. Albert, Almgren, Peter, Osmark, Peter, Bouatia-Naji, Nabila, Wierup, Nils, Fall, Tove, Stančáková, Alena, Barker, Adam, Lagou, Vasiliki, Osmond, Clive, Xie, Weijia, Lahti, Jari, Jackson, Anne U., Cheng, Yu-Ching, Liu, Jie, O'Connell, Jeffrey R., Blomstedt, Paul A., Fadista, Joao, Alkayyali, Sami, Dayeh, Tasnim, Ahlqvist, Emma, Taneera, Jalal, Lecoeur, Cecile, Kumar, Ashish, Hansson, Ola, Hansson, Karin, Voight, Benjamin F., Kang, Hyun Min, Levy-Marchal, Claire, Vatin, Vincent, Palotie, Aarno, Syvänen, Ann-Christine, Mari, Andrea, Weedon, Michael N., Loos, Ruth J. F., Ong, Ken K., Nilsson, Peter, Isomaa, Bo, Tuomi, Tiinamaija, Wareham, Nicholas J., Stumvoll, Michael, Widen, Elisabeth, Lakka, Timo A., Langenberg, Claudia, Tönjes, Anke, Rauramaa, Rainer, Kuusisto, Johanna, Frayling, Timothy M., Froguel, Philippe, Walker, Mark, Eriksson, Johan G., Ling, Charlotte, Kovacs, Peter, Ingelsson, Erik, McCarthy, Mark I., Shuldiner, Alan R., Silver, Kristi D., Laakso, Markku, Groop, Leif, Lyssenko, Valeriya
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974640/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974640/

Similar Items