Prolyl-hydroxylase 3: evolving roles for an ancient signaling protein

The ability of cells to sense oxygen is a highly evolved process that facilitates adaptations to the local oxygen environment and is critical to energy homeostasis. In vertebrates, this process is largely controlled by three intracellular prolyl-4-hydroxylases (PHD) 1–3. These related enzymes share...

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Bibliographic Details
Main Authors: Place, Trenton L, Domann, Frederick E
Format: Online
Language:English
Published: Dove Medical Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963164/