NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa

A TPCN1 gene–deficient mouse strain is used to show that two convergent working NAADP-dependent pathways with nonoverlapping activation and self-inactivation profiles for distinct NAADP concentrations drive acrosomal exocytosis, by which TPC1 is central for the pathway activated by low-micromolar NA...

Full description

Bibliographic Details
Main Authors: Arndt, Lilli, Castonguay, Jan, Arlt, Elisabeth, Meyer, Dorke, Hassan, Sami, Borth, Heike, Zierler, Susanna, Wennemuth, Gunther, Breit, Andreas, Biel, Martin, Wahl-Schott, Christian, Gudermann, Thomas, Klugbauer, Norbert, Boekhoff, Ingrid
Format: Online
Language:English
Published: The American Society for Cell Biology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952862/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952862/

Similar Items