Trichostatin A Suppresses EGFR Expression through Induction of MicroRNA-7 in an HDAC-Independent Manner in Lapatinib-Treated Cells

Trichostatin A Suppresses EGFR Expression through Induction of MicroRNA-7 in an HDAC-Independent Manner in Lapatinib-Treated Cells

Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, has been shown to improve the survival rate of patients with advanced HER2-positive breast cancers. However, the off-target activity of lapatinib in inducing EGFR expression without tyrosine kinase activity was demonstrated to render HER2-negati...

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Bibliographic Details
Main Authors: Tu, Chih-Yen, Chen, Chia-Hung, Hsia, Te-Chun, Hsu, Min-Hsiang, Wei, Ya-Ling, Yu, Meng-Chieh, Chen, Wen-Shu, Hsu, Ke-Wei, Yeh, Ming-Hsin, Liu, Liang-Chih, Chen, Yun-Ju, Huang, Wei-Chien
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950925/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950925/

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