Structure of Aurora B–INCENP in complex with barasertib reveals a potential transinhibitory mechanism

Two structures of Aurora B kinase bound to the specific inhibitor barasertib and to a nonhydrolyzable nucleotide provide evidences for a potential transinhibitory mechanism.

Bibliographic Details
Main Authors: Sessa, Fabio, Villa, Fabrizio
Format: Online
Language:English
Published: International Union of Crystallography 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944688/