Targeting the INCENP IN-box–Aurora B interaction to inhibit CPC activity in vivo
The chromosome passenger complex (CPC) is an essential regulator of mitosis and cytokinesis. The CPC consists of Aurora B kinase, inner centromere protein (INCENP), and the targeting subunits survivin and borealin/Dasra B. INCENP is a scaffolding subunit for the CPC and activates Aurora B via its co...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Royal Society
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248066/ |