Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
Mdm2, a ubiquitin ligase and downstream effector of p53, attenuates the proliferative potential of primary cells via ubiquitination and degradation of the glycolytic enzyme PGAM under senescence-inducing stress.
Bibliographic Details
| Main Authors: |
Mikawa, Takumi,
Maruyama, Takeshi,
Okamoto, Koji,
Nakagama, Hitoshi,
Lleonart, Matilde E.,
Tsusaka, Takeshi,
Hori, Kousuke,
Murakami, Itsuo,
Izumi, Taisuke,
Takaori-Kondo, Akifumi,
Yokode, Masayuki,
Peters, Gordon,
Beach, David,
Kondoh, Hiroshi |
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| Format: | Online
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| Language: | English |
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| Published: |
The Rockefeller University Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941061/
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