Vinculin Binding Angle in Podosomes Revealed by High Resolution Microscopy

Podosomes are highly dynamic actin-rich adhesive structures formed predominantly by cells of the monocytic lineage, which degrade the extracellular matrix. They consist of a core of F-actin and actin-regulating proteins, surrounded by a ring of adhesion-associated proteins such as vinculin. We have...

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Bibliographic Details
Main Authors: Walde, Marie, Monypenny, James, Heintzmann, Rainer, Jones, Gareth E., Cox, Susan
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921150/