Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

High-affinity transferrin receptor (TfR) bispecific antibodies facilitate trafficking of TfR to lysosomes and induce TfR degradation to decrease the ability of TfR to mediate BBB transcytosis.

Bibliographic Details
Main Authors:	Bien-Ly, Nga, Yu, Y. Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C. Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S., Weimer, Robby M., Chung, Inhee, Watts, Ryan J.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920563/

Similar Items

Regulation of mitochondrial morphology and function by Stearoylation of TfR1
by: Senyilmaz, Deniz, et al.
Published: (2015)

Evaluating the effectiveness of transferrin receptor‐1 (TfR1) as a magnetic resonance reporter gene
by: Pereira, Sofia M., et al.
Published: (2016)

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling
by: Kenneth, Niall S., et al.
Published: (2012)

Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71
by: Parenti, Rosalba, et al.
Published: (2014)

Dual single-scission event analysis of constitutive transferrin receptor (TfR) endocytosis and ligand-triggered β2-adrenergic receptor (β2AR) or Mu-opioid receptor (MOR) endocytosis
by: Lampe, Marko, et al.
Published: (2014)

The extrahepatic role of TFR2 in iron homeostasis
by: Silvestri, Laura, et al.
Published: (2014)

Measurement of serum transferrin receptor (sTfR) in critically ill patients
by: Kolias, S, et al.
Published: (2001)

In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact
by: Rishi, Gautam, et al.
Published: (2013)

Plasticity of melanoma and EMT-TF reprogramming
by: Tulchinsky, Eugene, et al.
Published: (2013)

Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
by: Chung, Yeonseok, et al.
Published: (2011)

Prevalence of Anaemia and Evaluation of Transferrin Receptor (sTfR) in the Diagnosis of Iron Deficiency in the Hospitalized Elderly Patients: Anaemia Clinical Studies in Chile
by: López-Sierra, Mauricio, et al.
Published: (2012)

Inflammatory macrophage phenotype in BTBR T+tf/J mice
by: Onore, Charity E., et al.
Published: (2013)

Expression of antigen tf and galectin-3 in fibroadenoma
by: Gallegos, Itandehui Belem, et al.
Published: (2012)

The sources of AML/СTF legislation: concept description
by: M M Proshunin
Published: (2008-12-01)

TfAP-2 is required for night sleep in Drosophila
by: Kucherenko, Mariya M., et al.
Published: (2016)

Impact of sodium butyrate and mild hypothermia on metabolic and physiological behaviour of CHO TF 70R cells
by: Veronica Avello, et al.
Published: (2017-05-01)

Generation and functional characterization of the anti-transferrin receptor single-chain antibody-GAL4 (TfRscFv-GAL4) fusion protein
by: Ye, Qing, et al.
Published: (2012)

Physicochemical Properties of PEMA-MgTf2-EMITFSI Polymer Electrolytes
by: Zain, N.F., et al.
Published: (2016)

Multiple non-collinear TF-map alignments of promoter regions
by: Blanco, Enrique, et al.
Published: (2007)

Modulation of COUP-TF Expression in a Cnidarian by Ectopic Wnt Signalling and Allorecognition
by: Duffy, David J., et al.
Published: (2011)

Transcriptional regulation via TF-modifying enzymes: an integrative model-based analysis
by: Everett, Logan J., et al.
Published: (2011)

The emerging role of neutrophils in thrombosis—the journey of TF through NETs
by: Kambas, Konstantinos, et al.
Published: (2012)

P2TF: a comprehensive resource for analysis of prokaryotic transcription factors
by: Ortet, Philippe, et al.
Published: (2012)

Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments
by: Kheradpour, Pouya, et al.
Published: (2014)

Identifying TF-MiRNA Regulatory Relationships Using Multiple Features
by: Shao, Mingyu, et al.
Published: (2015)

Use of BODIPY‐Cholesterol (TF‐Chol) for Visualizing Lysosomal Cholesterol Accumulation
by: Hölttä‐Vuori, Maarit, et al.
Published: (2016)

CardioTF, a database of deconstructing transcriptional circuits in the heart system
by: Zhen, Yisong
Published: (2016)

The TF-miRNA Coregulation Network in Oral Lichen Planus
by: Zuo, Yu-Ling, et al.
Published: (2015)

Long-term stability of the MR system of the Philips Ingenuity TF
by: Teuho, Jarmo, et al.
Published: (2015)

Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf/J mice
by: Amodeo, Dionisio A., et al.
Published: (2014)

Draft Whole-Genome Sequence of the Type Strain Bacillus aquimaris TF12T
by: Hernández-González, Ismael L., et al.
Published: (2016)

Exploring lateral genetic transfer among microbial genomes using TF-IDF
by: Cong, Yingnan, et al.
Published: (2016)

AkzoNobel joins together for sustainability (TfS) to enhance global supply chain
by: ,
Published: (2014)

Improving journeys by opening data: the case of Transport for London (TfL)
by: Merlin, Stone, et al.
Published: (2018)

N-Linked Glycosylation Is Required for Transferrin-Induced Stabilization of Transferrin Receptor 2, but Not for Transferrin Binding or Trafficking to the Cell Surface
by: Zhao, Ningning, et al.
Published: (2013)

An Electrochemical Study of PCl3 and POCl3 in the Room Temperature Ionic Liquid [C4mpyrr][N(Tf)2]
by: Silvester, Debbie, et al.
Published: (2006)

Electrochemical reduction of nitrobenzene and 4-nitrophenol in the room temperature ionic liquid [C4dmim][N(Tf)2]
by: Silvester, Debbie, et al.
Published: (2006)

Delivering TfL's Investment Programme: A Knowledge Integration Ethos for Middle Managers
by: Mensah, Emmanuel Edmondson
Published: (2006)

The role of social media to make singers in China—One case study of TF BOYS
by: Zhang, Mengru
Published: (2017)

Improving multi-term topics focused crawling by introducing term Frequency-Information Content (TF-IC) measure
by: Pesaranghader, Ali, et al.
Published: (2013)