Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

High-affinity transferrin receptor (TfR) bispecific antibodies facilitate trafficking of TfR to lysosomes and induce TfR degradation to decrease the ability of TfR to mediate BBB transcytosis.

Bibliographic Details
Main Authors: Bien-Ly, Nga, Yu, Y. Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C. Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S., Weimer, Robby M., Chung, Inhee, Watts, Ryan J.
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920563/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920563/

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