Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus

The zebrafish epithalamus is part of the diencephalon and encompasses three major components: the pineal, the parapineal and the habenular nuclei. Using sox2 knockdown, we show here that this key transcriptional regulator has pleiotropic effects during the development of these structures. Sox2 negat...

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Main Authors:	Pavlou, Sofia, Astell, Katy, Kasioulis, Ioannis, Gakovic, Milica, Baldock, Richard, van Heyningen, Veronica, Coutinho, Pedro
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909122/

id	pubmed-3909122
recordtype	oai_dc
spelling	pubmed-39091222014-02-04 Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus Pavlou, Sofia Astell, Katy Kasioulis, Ioannis Gakovic, Milica Baldock, Richard van Heyningen, Veronica Coutinho, Pedro Research Article The zebrafish epithalamus is part of the diencephalon and encompasses three major components: the pineal, the parapineal and the habenular nuclei. Using sox2 knockdown, we show here that this key transcriptional regulator has pleiotropic effects during the development of these structures. Sox2 negatively regulates pineal neurogenesis. Also, Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling. The correct levels of sox2 are critical for the functionally important asymmetrical positioning of the parapineal organ and for the migration of parapineal cells as a coherent structure. Deviations from this strict control result in defects associated with abnormal habenular laterality, which we have documented and quantified in sox2 morphants. Public Library of Science 2014-01-31 /pmc/articles/PMC3909122/ /pubmed/24498133 http://dx.doi.org/10.1371/journal.pone.0087546 Text en © 2014 Pavlou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pavlou, Sofia Astell, Katy Kasioulis, Ioannis Gakovic, Milica Baldock, Richard van Heyningen, Veronica Coutinho, Pedro
spellingShingle	Pavlou, Sofia Astell, Katy Kasioulis, Ioannis Gakovic, Milica Baldock, Richard van Heyningen, Veronica Coutinho, Pedro Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus
author_facet	Pavlou, Sofia Astell, Katy Kasioulis, Ioannis Gakovic, Milica Baldock, Richard van Heyningen, Veronica Coutinho, Pedro
author_sort	Pavlou, Sofia
title	Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus
title_short	Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus
title_full	Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus
title_fullStr	Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus
title_full_unstemmed	Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus
title_sort	pleiotropic effects of sox2 during the development of the zebrafish epithalamus
description	The zebrafish epithalamus is part of the diencephalon and encompasses three major components: the pineal, the parapineal and the habenular nuclei. Using sox2 knockdown, we show here that this key transcriptional regulator has pleiotropic effects during the development of these structures. Sox2 negatively regulates pineal neurogenesis. Also, Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling. The correct levels of sox2 are critical for the functionally important asymmetrical positioning of the parapineal organ and for the migration of parapineal cells as a coherent structure. Deviations from this strict control result in defects associated with abnormal habenular laterality, which we have documented and quantified in sox2 morphants.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909122/
_version_	1612053511404519424

Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus

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