In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants
The aggregation of alpha-synuclein (α-SYN) into fibrils is characteristic for several neurodegenerative diseases, including Parkinson’s disease (PD). Ninety percent of α-SYN deposited in Lewy Bodies, a pathological hallmark of PD, is phosphorylated on serine129. α-SYN can also be phosphorylated on t...
Main Authors: | Schreurs, Sarah, Gerard, Melanie, Derua, Rita, Waelkens, Etienne, Taymans, Jean-Marc, Baekelandt, Veerle, Engelborghs, Yves |
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Format: | Online |
Language: | English |
Published: |
Molecular Diversity Preservation International (MDPI)
2014
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907855/ |
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