HIF-1-Dependent Induction of Jumonji Domain-Containing Protein (JMJD) 3 under Hypoxic Conditions

HIF-1-Dependent Induction of Jumonji Domain-Containing Protein (JMJD) 3 under Hypoxic Conditions

Jumonji domain-containing proteins (JMJD) catalyze the oxidative demethylation of a methylated lysine residue of histones by using O2, α-ketoglutarate, vitamin C, and Fe(II). Several JMJDs are induced by hypoxic stress to compensate their presumed reduction in catalytic activity under hypoxia. In th...

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Bibliographic Details
Main Authors: Lee, Ho-Youl, Choi, Kang, Oh, Hookeun, Park, Young-Kwon, Park, Hyunsung
Format: Online
Language:English
Published: Korea Society for Molecular and Cellular Biology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907005/

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