Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆

Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an “unhealthy aging” phenotype) or mortality in 700, more than 85-year-o...

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Main Authors: Collerton, Joanna, Ashok, Deepthi, Martin-Ruiz, Carmen, Pyle, Angela, Hudson, Gavin, Yadegarfar, Mohammad, Davies, Karen, Jagger, Carol, von Zglinicki, Thomas, Kirkwood, Thomas B.L., Chinnery, Patrick F.
Format: Online
Language:English
Published: Elsevier 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906612/
id pubmed-3906612
recordtype oai_dc
spelling pubmed-39066122014-01-30 Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆ Collerton, Joanna Ashok, Deepthi Martin-Ruiz, Carmen Pyle, Angela Hudson, Gavin Yadegarfar, Mohammad Davies, Karen Jagger, Carol von Zglinicki, Thomas Kirkwood, Thomas B.L. Chinnery, Patrick F. Genetic Reports Abstract Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an “unhealthy aging” phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging. Elsevier 2013-12 /pmc/articles/PMC3906612/ /pubmed/23639206 http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.001 Text en © 2013 The Authors https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Collerton, Joanna
Ashok, Deepthi
Martin-Ruiz, Carmen
Pyle, Angela
Hudson, Gavin
Yadegarfar, Mohammad
Davies, Karen
Jagger, Carol
von Zglinicki, Thomas
Kirkwood, Thomas B.L.
Chinnery, Patrick F.
spellingShingle Collerton, Joanna
Ashok, Deepthi
Martin-Ruiz, Carmen
Pyle, Angela
Hudson, Gavin
Yadegarfar, Mohammad
Davies, Karen
Jagger, Carol
von Zglinicki, Thomas
Kirkwood, Thomas B.L.
Chinnery, Patrick F.
Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆
author_facet Collerton, Joanna
Ashok, Deepthi
Martin-Ruiz, Carmen
Pyle, Angela
Hudson, Gavin
Yadegarfar, Mohammad
Davies, Karen
Jagger, Carol
von Zglinicki, Thomas
Kirkwood, Thomas B.L.
Chinnery, Patrick F.
author_sort Collerton, Joanna
title Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆
title_short Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆
title_full Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆
title_fullStr Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆
title_full_unstemmed Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old☆
title_sort frailty and mortality are not influenced by mitochondrial dna haplotypes in the very old☆
description Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an “unhealthy aging” phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging.
publisher Elsevier
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906612/
_version_ 1612052760909316096

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