Sodium fluoride disrupts DNA methylation of H19 and Peg3 imprinted genes during the early development of mouse embryo

Sodium fluoride (NaF) is associated with embryonic and fetal development abnormalities, but the mechanism by which this occurs is unclear. DNA methylation, an important epigenetic reprogramming mechanism, is essential for normal embryonic development. Thus, we investigated the effect of NaF on DNA m...

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Bibliographic Details
Main Authors: Zhu, Jia-Qiao, Si, Yang-Jun, Cheng, Lai-Yang, Xu, Bao-Zeng, Wang, Qi-Wen, Zhang, Xiao, Wang, Heng, Liu, Zong-Ping
Format: Online
Language:English
Published: Springer Berlin Heidelberg 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906544/