BAG5 Protects against Mitochondrial Oxidative Damage through Regulating PINK1 Degradation

Mutations in PTEN-induced kinase 1 (PINK1) gene cause PARK6 familial Parkinsonism, and loss of the stability of PINK1 may also contribute to sporadic Parkinson's disease (PD). Degradation of PINK1 occurs predominantly through the ubiquitin proteasome system (UPS), however, to date, few of the p...

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Main Authors: Wang, Xuejing, Guo, Jifeng, Fei, Erkang, Mu, Yingfeng, He, Shuang, Che, Xiangqian, Tan, Jieqiong, Xia, Kun, Zhang, Zhuohua, Wang, Guanghui, Tang, Beisha
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901670/