Genome flexibility in Neisseria meningitidis
Neisseria meningitidis usually lives as a commensal bacterium in the upper airways of humans. However, occasionally some strains can also cause life-threatening diseases such as sepsis and bacterial meningitis. Comparative genomics demonstrates that only very subtle genetic differences between carri...
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| Format: | Online |
| Language: | English |
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Elsevier Science
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898611/ |
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pubmed-38986112014-01-24 Genome flexibility in Neisseria meningitidis Schoen, Christoph Tettelin, Hervé Parkhill, Julian Frosch, Matthias Article Neisseria meningitidis usually lives as a commensal bacterium in the upper airways of humans. However, occasionally some strains can also cause life-threatening diseases such as sepsis and bacterial meningitis. Comparative genomics demonstrates that only very subtle genetic differences between carriage and disease strains might be responsible for the observed virulence differences and that N. meningitidis is, evolutionarily, a very recent species. Comparative genome sequencing also revealed a panoply of genetic mechanisms underlying its enormous genomic flexibility which also might affect the virulence of particular strains. From these studies, N. meningitidis emerges as a paradigm for organisms that use genome variability as an adaptation to changing and thus challenging environments. Elsevier Science 2009-06-24 /pmc/articles/PMC3898611/ /pubmed/19477564 http://dx.doi.org/10.1016/j.vaccine.2009.04.064 Text en © 2009 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Schoen, Christoph Tettelin, Hervé Parkhill, Julian Frosch, Matthias |
| spellingShingle |
Schoen, Christoph Tettelin, Hervé Parkhill, Julian Frosch, Matthias Genome flexibility in Neisseria meningitidis |
| author_facet |
Schoen, Christoph Tettelin, Hervé Parkhill, Julian Frosch, Matthias |
| author_sort |
Schoen, Christoph |
| title |
Genome flexibility in Neisseria meningitidis |
| title_short |
Genome flexibility in Neisseria meningitidis |
| title_full |
Genome flexibility in Neisseria meningitidis |
| title_fullStr |
Genome flexibility in Neisseria meningitidis |
| title_full_unstemmed |
Genome flexibility in Neisseria meningitidis |
| title_sort |
genome flexibility in neisseria meningitidis |
| description |
Neisseria meningitidis usually lives as a commensal bacterium in the upper airways of humans. However, occasionally some strains can also cause life-threatening diseases such as sepsis and bacterial meningitis. Comparative genomics demonstrates that only very subtle genetic differences between carriage and disease strains might be responsible for the observed virulence differences and that N. meningitidis is, evolutionarily, a very recent species. Comparative genome sequencing also revealed a panoply of genetic mechanisms underlying its enormous genomic flexibility which also might affect the virulence of particular strains. From these studies, N. meningitidis emerges as a paradigm for organisms that use genome variability as an adaptation to changing and thus challenging environments. |
| publisher |
Elsevier Science |
| publishDate |
2009 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898611/ |
| _version_ |
1612050044293218304 |