Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

Infections with helminth parasites prevent/attenuate auto-inflammatory disease. Here we show that molecules secreted by a helminth parasite could prevent Type 1 Diabetes (T1D) in nonobese diabetic (NOD) mice. When delivered at 4 weeks of age (coincident with the initiation of autoimmunity), the excr...

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Bibliographic Details
Main Authors: Lund, Maria E., O'Brien, Bronwyn A., Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., Dalton, John P., Donnelly, Sheila
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897667/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897667/

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