Helminth defence molecules—immunomodulators designed by parasites!

by Robinson, Mark W., Donnelly, Sheila, Dalton, John P.
Published 2013

A novel method for large-scale culture of Plasmodium falciparum asexual blood stage and gametocytes in a Wave Bioreactor cell culture system

by Demanga, Corine G, Eng, Jenny, Dalton, John P
Published 2012

Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases

by El Ridi, Rashika, Tallima, Hatem, Dalton, John P., Donnelly, Sheila
Published 2014

A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis

by Ricciardi, Alessandra, Visitsunthorn, Kittipos, Dalton, John P., Ndao, Momar
Published 2016

Induction of Protective Immune Responses Against Schistosomiasis haematobium in Hamsters and Mice Using Cysteine Peptidase-Based Vaccine

by Tallima, Hatem, Dalton, John P., El Ridi, Rashika
Published 2015

The Plasmodium falciparum Malaria M1 Alanyl Aminopeptidase (PfA-M1): Insights of Catalytic Mechanism and Function from MD Simulations

by Jones, Peter M., Robinson, Mark W., Dalton, John P., George, Anthony M.
Published 2011

Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?

by Cotton, Sophie, Donnelly, Sheila, Robinson, Mark W., Dalton, John P., Thivierge, Karine
Published 2012

The Diagnosis of Human Fascioliasis by Enzyme-Linked Immunosorbent Assay (ELISA) Using Recombinant Cathepsin L Protease

by Gonzales Santana, Bibiana, Dalton, John P., Vasquez Camargo, Fabio, Parkinson, Michael, Ndao, Momar
Published 2013

A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides

by Robinson, Mark W., Donnelly, Sheila, Hutchinson, Andrew T., To, Joyce, Taylor, Nicole L., Norton, Raymond S., Perugini, Matthew A., Dalton, John P.
Published 2011

Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity

by El Ridi, Rashika, Tallima, Hatem, Selim, Sahar, Donnelly, Sheila, Cotton, Sophie, Gonzales Santana, Bibiana, Dalton, John P.
Published 2014

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

by Lund, Maria E., O'Brien, Bronwyn A., Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., Dalton, John P., Donnelly, Sheila
Published 2014

Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum

by Poreba, Marcin, McGowan, Sheena, Skinner-Adams, Tina S., Trenholme, Katharine R., Gardiner, Donald L., Whisstock, James C., To, Joyce, Salvesen, Guy S., Dalton, John P., Drag, Marcin
Published 2012

Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica

by Robinson, Mark W., Corvo, Ileana, Jones, Peter M., George, Anthony M., Padula, Matthew P., To, Joyce, Cancela, Martin, Rinaldi, Gabriel, Tort, Jose F., Roche, Leda, Dalton, John P.
Published 2011

Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation

by Thivierge, Karine, Cotton, Sophie, Schaefer, Deborah A., Riggs, Michael W., To, Joyce, Lund, Maria E., Robinson, Mark W., Dalton, John P., Donnelly, Sheila M.
Published 2013

Unexpected Activity of a Novel Kunitz-type Inhibitor: INHIBITION OF CYSTEINE PROTEASES BUT NOT SERINE PROTEASES *

by Smith, David, Tikhonova, Irina G., Jewhurst, Heather L., Drysdale, Orla C., Dvořák, Jan, Robinson, Mark W., Cwiklinski, Krystyna, Dalton, John P.
Published 2016

Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans

by Garcia-Campos, Andres, Ravidà, Alessandra, Nguyen, D. Linh, Cwiklinski, Krystyna, Dalton, John P., Hokke, Cornelis H., O’Neill, Sandra, Mulcahy, Grace
Published 2016

Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host*

by Ravidà, Alessandra, Cwiklinski, Krystyna, Aldridge, Allison M., Clarke, Paul, Thompson, Roisin, Gerlach, Jared Q., Kilcoyne, Michelle, Hokke, Cornelis H., Dalton, John P., O'Neill, Sandra M.
Published 2016

Fasciola hepatica vaccine: We may not be there yet but we’re on the right road

by Molina-Hernández, Verónica, Mulcahy, Grace, Pérez, Jose, Martínez-Moreno, Álvaro, Donnelly, Sheila, O’Neill, Sandra M., Dalton, John P., Cwiklinski, Krystyna
Published 2015

Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica

by Corvo, Ileana, O'Donoghue, Anthony J., Pastro, Lucía, Pi-Denis, Natalia, Eroy-Reveles, Alegra, Roche, Leda, McKerrow, James H., Dalton, John P., Craik, Charles S., Caffrey, Conor R., Tort, José F.
Published 2013

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

by Lund, Maria E., Greer, Judith, Dixit, Aakanksha, Alvarado, Raquel, McCauley-Winter, Padraig, To, Joyce, Tanaka, Akane, Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., O’Brien, Bronwyn A., Dalton, John P., Donnelly, Sheila
Published 2016