Overexpression of Dimethylarginine Dimethylaminohydrolase 1 Attenuates Airway Inflammation in a Mouse Model of Asthma

Overexpression of Dimethylarginine Dimethylaminohydrolase 1 Attenuates Airway Inflammation in a Mouse Model of Asthma

Levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, are increased in lung, sputum, exhaled breath condensate and plasma samples from asthma patients. ADMA is metabolized primarily by dimethylarginine dimethylaminohydrolase 1 (DDAH1) and DDAH2. We determine...

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Bibliographic Details
Main Authors: Kinker, Kayla G., Gibson, Aaron M., Bass, Stacey A., Day, Brandy P., Deng, Jingyuan, Medvedovic, Mario, Figueroa, Julio A. Landero, Hershey, Gurjit K. Khurana, Chen, Weiguo
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894860/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894860/

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