Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma

Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma

Rhabdomyosarcoma is the most commonly occurring soft-tissue sarcoma in childhood. Most rhabdomyosarcoma falls into one of two biologically distinct subgroups represented by alveolar or embryonal histology. The alveolar subtype harbors a translocation-mediated PAX3:FOXO1A fusion gene and has an extre...

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Bibliographic Details
Main Authors: Kikuchi, Ken, Hettmer, Simone, Aslam, M. Imran, Michalek, Joel E., Laub, Wolfram, Wilky, Breelyn A., Loeb, David M., Rubin, Brian P., Wagers, Amy J., Keller, Charles
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894165/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894165/

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