HIF-1alpha Expression Profile in Intratumoral and Peritumoral Inflammatory Cells as a Prognostic Marker for Squamous Cell Carcinoma of the Oral Cavity

HIF-1alpha Expression Profile in Intratumoral and Peritumoral Inflammatory Cells as a Prognostic Marker for Squamous Cell Carcinoma of the Oral Cavity

The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1alpha subunit is stabilized in hypoxia conditions, creating the HIF-1 nuclear transcription factor. In inflammatory cells, high HIF-1alpha expression induces lymph...

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Bibliographic Details
Main Authors: Mendes, Suzanny Oliveira, dos Santos, Marcelo, Peterle, Gabriela Tonini, Maia, Lucas de Lima, Stur, Elaine, Agostini, Lidiane Pignaton, de Carvalho, Marcos Brasilino, Tajara, Eloiza Helena, Louro, Iúri Drumond, Trivilin, Leonardo Oliveira, da Silva-Conforti, Adriana Madeira Álvares
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887011/

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