Determination of antiprotozoal drug mechanisms by metabolomics approaches
The discovery, development and optimal utilization of pharmaceuticals can be greatly enhanced by knowledge of their modes of action. However, many drugs currently on the market act by unknown mechanisms. Untargeted metabolomics offers the potential to discover modes of action for drugs that perturb...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Cambridge University Press
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884841/ |
| id |
pubmed-3884841 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-38848412014-01-08 Determination of antiprotozoal drug mechanisms by metabolomics approaches CREEK, DARREN J. BARRETT, MICHAEL P. Research Article The discovery, development and optimal utilization of pharmaceuticals can be greatly enhanced by knowledge of their modes of action. However, many drugs currently on the market act by unknown mechanisms. Untargeted metabolomics offers the potential to discover modes of action for drugs that perturb cellular metabolism. Development of high resolution LC-MS methods and improved data analysis software now allows rapid detection of drug-induced changes to cellular metabolism in an untargeted manner. Several studies have demonstrated the ability of untargeted metabolomics to provide unbiased target discovery for antimicrobial drugs, in particular for antiprotozoal agents. Furthermore, the utilization of targeted metabolomics techniques has enabled validation of existing hypotheses regarding antiprotozoal drug mechanisms. Metabolomics approaches are likely to assist with optimization of new drug candidates by identification of drug targets, and by allowing detailed characterization of modes of action and resistance of existing and novel antiprotozoal drugs. Cambridge University Press 2014-01 2013-06-05 /pmc/articles/PMC3884841/ /pubmed/23734876 http://dx.doi.org/10.1017/S0031182013000814 Text en © Cambridge University Press 2013 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence <http://creativecommons.org/licenses/by/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
CREEK, DARREN J. BARRETT, MICHAEL P. |
| spellingShingle |
CREEK, DARREN J. BARRETT, MICHAEL P. Determination of antiprotozoal drug mechanisms by metabolomics approaches |
| author_facet |
CREEK, DARREN J. BARRETT, MICHAEL P. |
| author_sort |
CREEK, DARREN J. |
| title |
Determination of antiprotozoal drug mechanisms by metabolomics approaches |
| title_short |
Determination of antiprotozoal drug mechanisms by metabolomics approaches |
| title_full |
Determination of antiprotozoal drug mechanisms by metabolomics approaches |
| title_fullStr |
Determination of antiprotozoal drug mechanisms by metabolomics approaches |
| title_full_unstemmed |
Determination of antiprotozoal drug mechanisms by metabolomics approaches |
| title_sort |
determination of antiprotozoal drug mechanisms by metabolomics approaches |
| description |
The discovery, development and optimal utilization of pharmaceuticals can be greatly enhanced by knowledge of their modes of action. However, many drugs currently on the market act by unknown mechanisms. Untargeted metabolomics offers the potential to discover modes of action for drugs that perturb cellular metabolism. Development of high resolution LC-MS methods and improved data analysis software now allows rapid detection of drug-induced changes to cellular metabolism in an untargeted manner. Several studies have demonstrated the ability of untargeted metabolomics to provide unbiased target discovery for antimicrobial drugs, in particular for antiprotozoal agents. Furthermore, the utilization of targeted metabolomics techniques has enabled validation of existing hypotheses regarding antiprotozoal drug mechanisms. Metabolomics approaches are likely to assist with optimization of new drug candidates by identification of drug targets, and by allowing detailed characterization of modes of action and resistance of existing and novel antiprotozoal drugs. |
| publisher |
Cambridge University Press |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884841/ |
| _version_ |
1612045515633983488 |