Timescales and bottlenecks in miRNA-dependent gene regulation

Timescales and bottlenecks in miRNA-dependent gene regulation

Application of a kinetic model of miRNA-mediated gene regulation to experimental data sets shows that the timescale of regulation is slower than previously assumed, due to bottlenecks imposed by miRNA turnover in the RNA-induced silencing complex and by slow protein decay.

Bibliographic Details
Main Authors: Hausser, Jean, Syed, Afzal Pasha, Selevsek, Nathalie, van Nimwegen, Erik, Jaskiewicz, Lukasz, Aebersold, Ruedi, Zavolan, Mihaela
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882800/
id pubmed-3882800
recordtype oai_dc
spelling pubmed-38828002014-01-07 Timescales and bottlenecks in miRNA-dependent gene regulation Hausser, Jean Syed, Afzal Pasha Selevsek, Nathalie van Nimwegen, Erik Jaskiewicz, Lukasz Aebersold, Ruedi Zavolan, Mihaela Article Application of a kinetic model of miRNA-mediated gene regulation to experimental data sets shows that the timescale of regulation is slower than previously assumed, due to bottlenecks imposed by miRNA turnover in the RNA-induced silencing complex and by slow protein decay. Nature Publishing Group 2013-12-03 /pmc/articles/PMC3882800/ /pubmed/24301800 http://dx.doi.org/10.1038/msb.2013.68 Text en Copyright © 2013, EMBO and Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Hausser, Jean
Syed, Afzal Pasha
Selevsek, Nathalie
van Nimwegen, Erik
Jaskiewicz, Lukasz
Aebersold, Ruedi
Zavolan, Mihaela
spellingShingle Hausser, Jean
Syed, Afzal Pasha
Selevsek, Nathalie
van Nimwegen, Erik
Jaskiewicz, Lukasz
Aebersold, Ruedi
Zavolan, Mihaela
Timescales and bottlenecks in miRNA-dependent gene regulation
author_facet Hausser, Jean
Syed, Afzal Pasha
Selevsek, Nathalie
van Nimwegen, Erik
Jaskiewicz, Lukasz
Aebersold, Ruedi
Zavolan, Mihaela
author_sort Hausser, Jean
title Timescales and bottlenecks in miRNA-dependent gene regulation
title_short Timescales and bottlenecks in miRNA-dependent gene regulation
title_full Timescales and bottlenecks in miRNA-dependent gene regulation
title_fullStr Timescales and bottlenecks in miRNA-dependent gene regulation
title_full_unstemmed Timescales and bottlenecks in miRNA-dependent gene regulation
title_sort timescales and bottlenecks in mirna-dependent gene regulation
description Application of a kinetic model of miRNA-mediated gene regulation to experimental data sets shows that the timescale of regulation is slower than previously assumed, due to bottlenecks imposed by miRNA turnover in the RNA-induced silencing complex and by slow protein decay.
publisher Nature Publishing Group
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882800/
_version_ 1612044889563856896

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