Timescales and bottlenecks in miRNA-dependent gene regulation
Application of a kinetic model of miRNA-mediated gene regulation to experimental data sets shows that the timescale of regulation is slower than previously assumed, due to bottlenecks imposed by miRNA turnover in the RNA-induced silencing complex and by slow protein decay.
Bibliographic Details
| Main Authors: |
Hausser, Jean,
Syed, Afzal Pasha,
Selevsek, Nathalie,
van Nimwegen, Erik,
Jaskiewicz, Lukasz,
Aebersold, Ruedi,
Zavolan, Mihaela |
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| Format: | Online
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| Language: | English |
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| Published: |
Nature Publishing Group
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882800/
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