HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

Deregulated expression of Hox genes such as HoxA9 is associated with development of myeloproliferative disorders and leukemia and indicates a poor prognosis. To investigate the molecular mechanisms by which HoxA9 promotes immortalization of hematopoietic cells, we generated growth factor dependent m...

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Bibliographic Details
Main Authors: Brumatti, Gabriela, Salmanidis, Marika, Kok, Chung H, Bilardi, Rebecca A, Sandow, Jarrod J, Silke, Natasha, Mason, Kylie, Visser, Jolanda, Jabbour, Anissa M, Glaser, Stefan P, Okamoto, Toru, Bouillet, Philippe, D'Andrea, Richard J, Ekert, Paul G
Format: Online
Language:English
Published: Impact Journals LLC 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875760/

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