The MTHFR C677T polymorphism and global DNA methylation in oral epithelial cells

The MTHFR C677T polymorphism and global DNA methylation in oral epithelial cells

DNA methylation is mediated by DNA methyltransferases (DNMTs) that add a methyl group to the 5′-carbon of cytosine. The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the rate-limiting step of the cycle invo...

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Bibliographic Details
Main Authors: de Arruda, Isabela Tatiana Sales, Persuhn, Darlene Camati, de Oliveira, Naila Francis Paulo
Format: Online
Language:English
Published: Sociedade Brasileira de Genética 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873177/

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