The MTHFR C677T polymorphism and global DNA methylation in oral epithelial cells
DNA methylation is mediated by DNA methyltransferases (DNMTs) that add a methyl group to the 5′-carbon of cytosine. The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the rate-limiting step of the cycle invo...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Sociedade Brasileira de Genética
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873177/ |