Co-Expression of SERCA Isoforms, Phospholamban and Sarcolipin in Human Skeletal Muscle Fibers

Co-Expression of SERCA Isoforms, Phospholamban and Sarcolipin in Human Skeletal Muscle Fibers

Sarcolipin (SLN) and phospholamban (PLN) inhibit the activity of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) by reducing their apparent affinity for Ca2+. A ternary complex between SLN, PLN, and SERCAs results in super-inhibition of SERCA activity. Analysis of skeletal muscle homogenate has l...

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Bibliographic Details
Main Authors: Fajardo, Val A., Bombardier, Eric, Vigna, Chris, Devji, Tahira, Bloemberg, Darin, Gamu, Daniel, Gramolini, Anthony O., Quadrilatero, Joe, Tupling, A. Russell
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865254/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865254/

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