Null anticarcinogenic effect of silymarin on diethylnitrosamine-induced hepatocarcinogenesis in rats

The aim of this study was to investigate the anticarcinogenic effects of silymarin in diethylnitrosamine (DEN)-induced hepatocarcinogenic rat models. Severe and mild models of hepatocellular carcinoma (HCC) were generated by the intraperitoneal administration of 40 mg/kg DEN once a week for 18 weeks...

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Bibliographic Details
Main Authors: IMAMOTO, RYU, OKANO, JUN-ICHI, SAWADA, SHINTARO, FUJISE, YUKI, ABE, RYO, MURAWAKI, YOSHIKAZU
Format: Online
Language:English
Published: D.A. Spandidos 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861306/