Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆

Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆

Diffuse intrinsic pontine glioma (DIPG) has a dismal prognosis with no chemotherapy regimen so far resulting in any significant improvement over standard radiotherapy. In this trial, a prolonged regimen (21/28 d) of temozolomide was studied with the aim of overcoming O6-methylguanine methyltransfera...

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Main Authors: Bailey, S., Howman, A., Wheatley, K., Wherton, D., Boota, N., Pizer, B., Fisher, D., Kearns, P., Picton, S., Saran, F., Gibson, M., Glaser, A., Connolly, D.J.A., Hargrave, D.
Format: Online
Language:English
Published: Elsevier Science Ltd 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853623/
id pubmed-3853623
recordtype oai_dc
spelling pubmed-38536232013-12-06 Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆ Bailey, S. Howman, A. Wheatley, K. Wherton, D. Boota, N. Pizer, B. Fisher, D. Kearns, P. Picton, S. Saran, F. Gibson, M. Glaser, A. Connolly, D.J.A. Hargrave, D. Article Diffuse intrinsic pontine glioma (DIPG) has a dismal prognosis with no chemotherapy regimen so far resulting in any significant improvement over standard radiotherapy. In this trial, a prolonged regimen (21/28 d) of temozolomide was studied with the aim of overcoming O6-methylguanine methyltransferase (MGMT) mediated resistance. Elsevier Science Ltd 2013-12 /pmc/articles/PMC3853623/ /pubmed/24011536 http://dx.doi.org/10.1016/j.ejca.2013.08.006 Text en © 2013 The Authors https://creativecommons.org/licenses/by-nc-sa/3.0/ Open Access under CC BY-NC-SA 3.0 (https://creativecommons.org/licenses/by-nc-sa/3.0/) license
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Bailey, S.
Howman, A.
Wheatley, K.
Wherton, D.
Boota, N.
Pizer, B.
Fisher, D.
Kearns, P.
Picton, S.
Saran, F.
Gibson, M.
Glaser, A.
Connolly, D.J.A.
Hargrave, D.
spellingShingle Bailey, S.
Howman, A.
Wheatley, K.
Wherton, D.
Boota, N.
Pizer, B.
Fisher, D.
Kearns, P.
Picton, S.
Saran, F.
Gibson, M.
Glaser, A.
Connolly, D.J.A.
Hargrave, D.
Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆
author_facet Bailey, S.
Howman, A.
Wheatley, K.
Wherton, D.
Boota, N.
Pizer, B.
Fisher, D.
Kearns, P.
Picton, S.
Saran, F.
Gibson, M.
Glaser, A.
Connolly, D.J.A.
Hargrave, D.
author_sort Bailey, S.
title Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆
title_short Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆
title_full Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆
title_fullStr Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆
title_full_unstemmed Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – Results of a United Kingdom phase II trial (CNS 2007 04)☆
title_sort diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy – results of a united kingdom phase ii trial (cns 2007 04)☆
description Diffuse intrinsic pontine glioma (DIPG) has a dismal prognosis with no chemotherapy regimen so far resulting in any significant improvement over standard radiotherapy. In this trial, a prolonged regimen (21/28 d) of temozolomide was studied with the aim of overcoming O6-methylguanine methyltransferase (MGMT) mediated resistance.
publisher Elsevier Science Ltd
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853623/
_version_ 1612035542466166784

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