Improving macrophage responses to therapeutic antibodies by molecular engineering of SIRPα variants
CD47 transduces inhibitory signals through signal-regulatory protein α (SIRPα), a plasma membrane receptor expressed by macrophages. Many cancers upregulate CD47 to evade immunosurveillance. We have recently engineered SIRPα variants that potently antagonize CD47 for use as anticancer immunotherapeu...
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Bibliographic Details
Main Authors: |
Weiskopf, Kipp,
Ring, Aaron M,
Schnorr, Peter J,
Volkmer, Jens-Peter,
Volkmer, Anne Kathrin,
Weissman, Irving L,
Garcia, K Christopher |
Format: | Online
|
Language: | English |
Published: |
Landes Bioscience
2013
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850276/
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