Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

Protein turnover of Patched, the Hedgehog receptor and key negative regulator of Hedgehog signaling, is controlled by the ubiquitin E3 ligase, Smurf, in a manner that depends on activation of signal transducer, Smoothened.

Bibliographic Details
Main Authors: Huang, Shoujun, Zhang, Zhao, Zhang, Chunxia, Lv, Xiangdong, Zheng, Xiudeng, Chen, Zhenping, Sun, Liwei, Wang, Hailong, Zhu, Yuanxiang, Zhang, Jing, Yang, Shuyan, Lu, Yi, Sun, Qinmiao, Tao, Yi, Liu, Feng, Zhao, Yun, Chen, Dahua
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841102/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841102/

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