Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
Pancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial char...
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| Format: | Online |
| Language: | English |
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MDPI
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840444/ |
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pubmed-38404442013-11-26 Epithelial-Mesenchymal Transition in Pancreatic Carcinoma Maier, Harald J. Wirth, Thomas Beug, Hartmut Review Pancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial characteristics and gain properties of mesenchymal cells, such as enhanced motility and invasive features. This review will discuss recent findings pertinent to EMT in pancreatic carcinoma. Evidence for and molecular characteristics of EMT in pancreatic carcinoma will be outlined, as well as the connection of EMT to related topics, e.g., cancer stem cells and drug resistance. MDPI 2010-12-09 /pmc/articles/PMC3840444/ /pubmed/24281218 http://dx.doi.org/10.3390/cancers2042058 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Maier, Harald J. Wirth, Thomas Beug, Hartmut |
| spellingShingle |
Maier, Harald J. Wirth, Thomas Beug, Hartmut Epithelial-Mesenchymal Transition in Pancreatic Carcinoma |
| author_facet |
Maier, Harald J. Wirth, Thomas Beug, Hartmut |
| author_sort |
Maier, Harald J. |
| title |
Epithelial-Mesenchymal Transition in Pancreatic Carcinoma |
| title_short |
Epithelial-Mesenchymal Transition in Pancreatic Carcinoma |
| title_full |
Epithelial-Mesenchymal Transition in Pancreatic Carcinoma |
| title_fullStr |
Epithelial-Mesenchymal Transition in Pancreatic Carcinoma |
| title_full_unstemmed |
Epithelial-Mesenchymal Transition in Pancreatic Carcinoma |
| title_sort |
epithelial-mesenchymal transition in pancreatic carcinoma |
| description |
Pancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial characteristics and gain properties of mesenchymal cells, such as enhanced motility and invasive features. This review will discuss recent findings pertinent to EMT in pancreatic carcinoma. Evidence for and molecular characteristics of EMT in pancreatic carcinoma will be outlined, as well as the connection of EMT to related topics, e.g., cancer stem cells and drug resistance. |
| publisher |
MDPI |
| publishDate |
2010 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840444/ |
| _version_ |
1612030591340904448 |