TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway
In the current study, we investigated the role of tribbles homolog 3 (TRIB3) in glucose-induced insulin resistance and whether the induction of TRIB3 by glucose is dependent on the nutrient-sensing hexosamine biosynthetic pathway (HBP) known to mediate glucose toxicity in diabetes. In diabetic rats,...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Diabetes Association
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837074/ |